Aryl alkyl sulfides and diaryl sulfides are important and useful compounds in organic synthesis and pharmaceutical industries.1 Classical method for of sulfides is the reaction of an organosulfur nucleophile with an organic halide sources in the presence of transition metals.2-3 Herin, we present for the firsttime several new strategies for one-pot odorless synthesis of a wide range of unsymmetrical sulfides from the fallowing reactions: (1) The reaction of triphenyltin chloride as the source of phenyl group with compounds such as aryl halides, phenolic esters and nitroarenes in the presence of S8 as sulfur source, potassium fluoride as sulfur activator, potassium carbonate as base and copper (II) acetate as a catalyst in polyethylene glycol (PEG) as an eco-friendly medium . (2) The reaction of aryl boronic acids with aryl halides, phenolic esters or nitroarenes in the presence of S8, NaOH or NaOtBu and catalytic amount of CuI in PEG as green solvent . Also , we have developed an efficient and odorless method for the synthesis . Finally, the synthesis of symmetrical diaryl sulfides from aryl halides and phenolic esters using S8 as the sulfur source is described . Important features of these procedures are as follows: (i) relieving from unclean-smelling thiols which makes the methods more easy and practical (ii) using a commercially available, inexpensive, and chemically stable sulfur sources, starting materials and catalysts.
