Vanadium complex of pseudoephedrine immobilized on magnetic nanoparticle Fe3O4[VO(Pseudoephedrine)@MNPs] was prepared and characterized by UV–vis, SEM, XRD, TGA, EDX, FT-IR, AGFM and elemental analysistechniques. VO(pseudoephedrine)@MNPs was found to catalyze the cyanosilylation of carbonyl compounds using TMSCN in good yields with 8–25% enantiomeric excesses under solvent-free conditions at room temperature. The catalyst was recycled up to 15 times with little loss of activity and enantioselectivity