Amides play an crucial role in structure of building blocks such as natural, organic, pharmaceutical, biological and agricultural productts. They are very important intermediates in the synthesis of some drugs and chemicals they also act as ligands for heterogeneous and homogeneous catalysts in the synthesis of other compounds also [1]. Due to the high importance of amides, several methods have been developed for their synthesis such as the C-H functionalization of aldehyde with amines using homogenous catalysts [2]. Palladium in homogenous form, provided many sites to activate many organic functional groups and its ability converted desired compounds to excellent catalysts for chemical reactions involving and is one of the prominent features of this reaction because of its stabilitiy, availability and selectivity [3]. In this work, in order to develop an innovative approach toward for C-N bond formation reactions, C-H bond from aldehyde is broked on surface of palladium and then amine inserted to Pd-C bond. In general p-chloro-N-tosylbenzamide synthesized by addition of p-toluene sulfonamide 2 to aromatic aldehyde 1 in the presence of a organometalic catalyst Pd salts and phosphine ligand in the optimum condition in excellent yields and short reaction time (Scheme 1). The structure of products is characterized by melting point and IR, 1H NMR, and 13C NMR spectroscopies.
