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Title
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Synthesis of 3-Pyrroline-5-ones in α-Pinene
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Type
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Presentation
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Keywords
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3-Pyrroline-5-ones, α-Pinen, dialkyl acetylenedicarboxylates, triphenylphosphine
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Abstract
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N-substituted 3-pyrrolines are an important class of compounds with exhibit biological activities [1] and serve as useful synthetic intermediates [2]. There are also many examples of pyrroline containing natural products with interesting pharmacological activities [3]. We previously reported synthesis of 3-pyrroline-5-one derivatives by the three component reaction of ethyl 2-arylamino-2-oxoacetates and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine [4, 5]. We wish to report here reaction between achiral and chiral ethyl 2-arylamino-2-oxoacetates and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine in α-Pinene. The results show no enantioselectivity or diastereoselectivity when the reactions carried out in this solvent.
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Researchers
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MORTEZA Bidar (Fourth Researcher), koroush pourdavaee (Third Researcher), Fatemeh Nazem (Second Researcher), Farough Nasiri (First Researcher)
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