|
Title
|
Laccase-catalyzed in situ generation and regeneration of Nphenyltriazolinedione for the aerobic oxidative homo-coupling of thiols to disulfides
|
|
Type
|
JournalPaper
|
|
Keywords
|
Laccase enzyme,4-Phenyl urazole, Cooperative catalytic system, N-phenyltriazolinedione, Aerobic oxidative, Disulfides
|
|
Abstract
|
The first report on aerobic in situ generation and regeneration of N-phenyltriazolinedione, a valuable oxidizing agent, from a catalytic amount of N-phenyl urazole in the presence of a laccase enzyme is presented. The application of a 4-phenyl urazole/Laccase/O2 as a new cooperative catalytic oxidation system is reported for a transition-metal-free and halogen free oxidative homo-coupling reaction of structurally diverse thiols to their corresponding disulfides with good to excellent yields in a phosphate buffer solution under mild reaction conditions.
|
|
Researchers
|
Seyed Amir Zarei (Third Researcher), Amin Rostami (Second Researcher), Donya Khaledian (First Researcher)
|