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Title
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Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity
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Type
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JournalPaper
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Keywords
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Fe3O4 nanoparticles; antioxidant; synthesis; cytotoxic activity; chromenopyrimidinethiones
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Abstract
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The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe3O4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure–activity relationships for splitting antioxidant and cytotoxic activity of these compounds.
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Researchers
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Ali Ramazani (Second Researcher), Sang Woo Joo (Not In First Six Researchers), Alireza Foroumadi (Not In First Six Researchers), Abbas Shafiee (Not In First Six Researchers), Sussan Kaboudanian Ardestani (Not In First Six Researchers), Mehdi Khoshneviszadeh (Fifth Researcher), Zahra Hojjati (Third Researcher), Mehdi Khoobi (First Researcher), Raheleh Shakeri (Fourth Researcher)
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