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Title
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Ligand-free Cu-catalyzed odorless synthesis of unsymmetrical sulfides through cross-coupling reaction of aryl/benzyl/alkyl halides with an aryl boronic acid/S8 system as a thiolating agent in PEG
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Type
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JournalPaper
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Keywords
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sulfide, aryl boronic acid, aryl/benzyl/alkyl halide, S8, Cu, catalyst
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Abstract
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In this article, we have presented a novel, efficient and environmentally benign method for one-pot, one-step and odorless synthesis of a wide range of unsymmetrical sulfides from the reaction of aryl/benzyl/alkyl halides with aryl boronic acids in the presence of S8, NaOH and a catalytic amount of CuI in PEG200 as green solvent at 40–6 oC. The products were obtained in moderate to excellent yields. More importantly, this reaction is applicable for the gram-scale preparation of the desired sulfides.
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Researchers
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MohamadAli Zolfigol (Fourth Researcher), Arash Ghaderi (Third Researcher), Amin Rostami (Second Researcher), Abed Rostami (First Researcher)
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