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Title
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Antimicrobial activities of fused 2-amino-4H-pyranes derived from TOSMIC and acetylenic esters in the presence of cyclic CH-acids
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Type
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Presentation
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Keywords
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Antimicrobial activity, 2-amino-4H-pyran, Cyclic CH-acids
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Abstract
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During the last twenty years, the study the biological activity of chromene derivatives has been the aim of many scientists [1]. Fused chromenes are interested due to their significant antibacterial and novobiocin activity. The chemistry of poly functionalized 4H-pyranes are also an ongoing area of interest because of their wide range of applications [2]. We have perversely reported the reaction between cyclic and acyclic CH-acids with acetylenic esters in the presence of alkyl isocyanides to produce highly functionalized 2-amino-4H-pyranes [3,4]. In this work we wish to report the antimicrobial activities of fused 2-amino-4H-pyrane derivatives 1 and 2 derived from the reaction of TOSMIC and acetylenic esters in the presence of cyclic CH-acids against Gram-positive and Gram-negative bacteria. These activities were tested in vitro using two reference bacteria strains. e.g. Staphylococcus aureus and Escherichia coli. These compounds were active against both strains tested by disk diffusion method in ranging 6 to 17 mm per 1000 μg disk.
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Researchers
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Amin Zolali (Third Researcher), Rashid RamazanZadeh (Second Researcher), Farough Nasiri (First Researcher)
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