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Title
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Three component reaction between 1,3-dicarbonyl compounds and acetylenic esters in the presence of triphenylphosphine in aqueous media
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Type
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Presentation
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Keywords
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three component reactions, triphenylphosphine; nucleophiles;triçhenylphosphine
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Abstract
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There are many studies on the reaction between trivalent phosphorus nucleophiles and acetylenic esters in the presence of OH, NH, or CH acids [1-3]. In some cases ylide products ae stable, but in other cases they can not be Isolated and appear to occure as an intermediate on the pathway to an observed product. In many cases this reaction carried out in dry organic solvents such as dry dichloromethane or diethyl ether. In this work we wish to report the three component reaction of strong CH acids such as acetylacetone and acetylenic esters in the presence of triçhenylphosphine to produce highly functionalized stable phosphoruse ylieds in THF/H2O (1;1) in nearly quantitave yields at 20 mm. This methodology is of interest because the use of water as solvent and reduced the time of reaction, thus minimizing the cost, operational hazards and environmental pollution.
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Researchers
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Farough Nasiri (Second Researcher), MORTEZA Bidar (First Researcher)
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