In the management of water resources, quality of water is just as important as its quantity. The main aim of this study has been to assess the variability of groundwater parameters to develop water quality of Tirupati area and its suitability for domestic and irrigation purpose. Further, the samples were analyzed for pH, EC, TDS, carbonates, bicarbonates, alkalinity, chlorides, sulfates, hardness, fluoride, calcium, magnesium, sodium, and potassium. Based on the analytical results, chemical indices like percent sodium, sodium absorption ratio (SAR), adjusted SAR, percent sodium (Na %), residual sodium carbonate (RSC) and permeability index (PI) have been calculated. Chadha rectangular diagram for geochemical classification and hydrochemical processes of groundwater indicated that most of waters are Ca–Mg–HCO3 and Ca–Mg–Cl types. Assessment of water samples from various methods indicated that majority of the water samples are suitable for domestic and irrigation purpose