Ring heterocyclic molecules constitute the largest portion of chemical entities, which are part of many natural products and biologically active pharmaceuticals vital for enhancing the quality of life. Phathalazine derivatives, constituting a hydrazine are reported to process a multiplicity of pharmacological properties including anticonvulsant, vasorelaxant. , [Cu(CH3CN)4]PF6 as a highly effective catalyst catalyzes the three componenet reaction of aryl aldehydes, dimedone, phthalhydrazide at 80-100 ºC under solvent-free conditions for 2H-indazolo[2,1-b]phthalazine-trione derivatives, to be highly active for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives which can be prepared from inexpensive reagent and can be easily recycled. This method is quite simple, high yielding, time saving, and ecofriendly.
