Background: lack of mobility has an important role in the development of obesity in the elderly population. The purpose of this study was to investigate the effect of regular aerobic exercise and omega-3 supplementation on serum levels of CRP and IL-6 in elderly women were obese. Methods: In a double-blind study, 40 obese women (BMI ≥ 30) 61.65±7.42 years old were selected as easily-accessible way and randomly categorized into 4 groups of 10 subjects an exercise, supplementation, exercise – supplementation (combination), and placebo (control) groups. Subjects in the supplement and combination groups consumed 2080 mg omega-3 supplement daily for 8 weeks and control groups used sunflower oil as placebo produced in Zachariah Company. Exercise program included aerobic activity at 45 to 55 percent of maximum heart rate for 8 weeks, 40 minute and 3 sessions per week. Blood samples before and 24 hours after the training period in the fasting state were collected. Data analysis was done by paired-t test and two-way ANOVA test using SPSS software (version 16). Results: Statistical test results showed that the concentration of IL-6 and CRP were significantly decreased in the groups of exercise with supplements (p<0/05). Conclusion: The result of this study, carried out 8 weeks of aerobic training with omega-3 supplementation improves the inflammatory status Caused by exercise training combined with omega 3.
