Introduction: Excessive physical exercise overproduces reactive oxygen species. Even if elite sportsmen increase their antioxidant status by regular physical training, this improvement is not sufficient to limit free radical production during the competition period which can be detrimental to the body. This study evaluates the effect of grape seed supplementation along with aerobic exercise on lipid profile in elderly women. Materials and methods: In a double-blind study, 40 obese women (BMI≥30) upper 60 years old were randomly selected and divided into two groups of experimental (10 individuals) and control (10 individuals). The experimental group received 2 GE supplementation (100mg·d1) for 4 weeks. Exercise program included aerobic exercise activities at 45 to 60 percent of maximum heart rate for 4 weeks and three 60-minute sessions per week. Blood samples were collected after 12 hours fasting before the study and 48 hours after the last session of the study. One-way ANOVA followed by LSD test was used for the statistical analysis. Results: The results of the present study shows that there is a significant difference among amount of cholesterol, triglyceride and LDL-C before and after the study, but these amounts were not significant in the control group. Conclusion: According to the present study results, 4 weeks aerobic exercise can prevent atherosclerosis and improve people’s health and it can control and reduce atherosclerosis in obese individuals
