Background: Cardiovascular diseases are one of the main causes of morbidity and mortality in the world that the prevalence is increasing in Iran. This study investigated the effect of almond extract supplement combined with aerobic exercise on lipid profile in men with elevated blood lipids. Materials and methods: In a quasi-experimental design, 48 men aged 40±5 year-old were divided randomly into four groups: aerobic exercise group, aerobic exercise group plus consumption of almond, almond consumption group, and control group. The second and third groups consumed 60g almonds per day for 56 days.. Aerobic exercise was performed for eight weeks with or without almond. Blood samples were taken in two steps (before and after the test). Lipid profile was measured by spectrophotometry. The data was analyzed using analysis of variance and LSD test. Results: Eight weeks consumption of almond supplementation combined with exercise training had a significant effect on the base of lipid profile (p≤0.05). Lipid profiles were not significantly different in the groups without exercise (p>0.05). Conclusion: According to this study, it can be concluded that eight weeks consumption of almond supplementation combined with aerobic exercise has a greater influence on the lipid profile in obese men.