Using shear walls in different states of concrete, steel, or a combination of them as a lateral force resisting system is a common method in structures to deal with lateral loads. Until the 1990s, only reinforced concrete shear walls were widely used. For the last two decades, extensive studies and research have been conducted on steel and composite shear walls, and the use of these innovative systems in new structures has been increasing subsequently. In this study, the performance of composite steel plate shear walls with two openings was numerically investigated. Validation of the numerical model was compared with the results of other researchers’ experimental studies. In this numerical study, which was carried out with the help of ABAQUS finite element software, models with three opening positions in the middle of the wall, the upper and lower thirds of the wall with the openings’ area of 10%, 20%, 30%, and 40% compared to the total area of the wall, were modeled and analyzed under cyclic load. Results demonstrated that specimens without openings had the highest initial stiffness, and specimens with two openings had the lowest initial stiffness. Specimens having openings with a small opening area had the highest initial stiffness. By increasing the area of the openings, the ultimate strength of the composite shear wall system decreased, and the position of the openings had a negligible effect. In addition, the concrete layer played an essential role in increasing the strength of the wall.