1403/01/10
شمس الدین احمدی

شمس الدین احمدی

مرتبه علمی: دانشیار
ارکید: 0000-0003-0300-3226
تحصیلات: دکترای تخصصی
اسکاپوس: 12141695900
دانشکده: دانشکده علوم پایه
نشانی: سنندج، دانشگاه کردستان، دانشکده علوم پایه، گروه علوم زیستی
تلفن: 08733664600 (2510)

مشخصات پژوهش

عنوان
Anticancer activity assessment of two novel binuclear platinum (II) complexes
نوع پژوهش
JournalPaper
کلیدواژه‌ها
Anticancer drugs, Platinum complexes, Cancer cells, DNA damage, Apoptosis
سال
2016
مجله JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
شناسه DOI
پژوهشگران Mohammad Bagher Shahsavani ، Shamseddin Ahmadi ، Marzieh Dadkhah Aseman ، Masoud Nabavizadeh ، Mehdi Rashidi ، Zahra Asadi ، Nasrollah Erfani ، Atiyeh Ghasemi ، Ali Akbar Saboury ، Ali Niazi ، Aminollah Bahaoddini ، Reza Yousefi

چکیده

In the current study, two binuclear Pt (II) complexes, containing cis, cis-[Me2Pt (μ-NN) (μ-dppm) PtMe2] (1), and cis,cis-[Me2Pt(μ-NN)(μ dppm) Pt((CH2)4)] (2) in which NN = phthalazine and dppm = bis (diphenylphosphino) methane were evaluated for their anticancer activities and DNA/purine nucleotide binding properties. These Pt (II) complexes, with the non-classical structures, demonstrated a significant anticancer activity against Jurkat and MCF-7 cancer cell lines. The results of ethidium bromide/acridine orange staining and Caspase-III activity suggest that these complexes were capable to stimulate an apoptotic mechanism of cell death in the cancer cells. Using different biophysical techniques and docking simulation analysis, we indicated that these complexes were also capable to interact efficiently with DNA via a non-intercalative mechanism. According to our results, substitution of cyclopentane (in complex 2) with two methyl groups (in complex 1) results in significant improvement of the complex ability to interact with DNA and subsequently to induce the anticancer activity. Overall, these binuclear Pt (II) complexes are promising group of the non-classical potential anticancer agents which can be considered as molecular templates in designing of highly efficient platinum anticancer drugs.