There are many advantages for E-commerce as lower cost, economical way for communications, higher margin, better customer services, knowledge markets, swapping goods and services, and customization that they can provide a new mechanism for optimizing relationship with customers. As e-commerce grows across industries worldwide, business are building web sites for presence as well as for online business regarding to their organizational knowledge contexts. There is a presumption that we should consider OKM with its factors to increase using and adoption of e-commerce in developing countries. This process requires explaining main models, changing infrastructures, and notice to customer needs as their vital rights. The main infrastructure that has very important role in expansion of e-commerce in developing countries and related to the servicers is knowledge management factor. In this research we survey the relationship between e-commerce development and organizational knowledge management (OKM) and the correlation between two groups of variables are shown in final model. This paper integrates and extends research on e-commerce in the developing world. Then, we provide the case of an e-business model followed by an Iranian-based one.