This paper investigates the thermal comfort level of an office room through various windows-door opening arrangements. To determine the windows-door opening performance 14 opening configurations have been considered and the combination of opening arrangements was carried out in an office at UPM, Malaysia. After conducting objective measurement for each condition, Predicted Mean Vote (PMV) and predicted Percentage of Dissatisfied (PPD) were calculated. The subjective survey involved questions on the thermal environmental perception and indoor air quality for office occupants. Objective data analysis showed that in noneof conditions office had thermal conditions falling within the comfort zone of ASHRAE standard 55, and in all of conditions neutral temperatures are higher than ASHRAE standardrequirements. Subjective results revealed that staff has higher thermal comfort level as compared to what PMV has predicted.