Heat exchangers are very important equipment in chemical and process industries. For this reason, improving performance and increasing their efficiency has always been considered. In recent study, the thermal-hydraulic performance of three types of zigzag channels was investigated using Computational Fluid Dynamics (CFD). The V-bend zigzag Channels (VZC), the L-bend zigzag Channels (LZC), and the U-bend zigzag Channels (UZC) were studied. The length of all channels was equal to 2.3 meters and their hydraulic diameter was determined to be 0.01 meters. The working fluid in this study was water and the flow inside channels was turbulent and the Reynolds (Re) range was selected from 20000 to 60000. Fluid flow was considered to be fully developed. The standard k-epsilon model was used for modeling. Boundary and initial conditions for modeling were equal to constant temperature of 353 K for channels wall and temperature of inlet fluid to channel equal to 298 K. The VZC The zigzag channel had the best thermal performance, but at the same time, it also had the weakest hydraulic performance. The UZC had the best hydraulic performance and weakest thermal performance. In total, the THP of the UZC was higher and better than the other channels.