In the study, optimum parameters including geometries and flow characteristics related to the heat exchangers with corrugated channels were determined using the genetic algorithm technique. The optimum solutions or Pareto set obtained from the multi-objective optimization process. Any change in the heat exchanger can lead to an increase in pressure drop and subsequently an increase in pumping energy. Therefore, the Nusselt number (Nu) and pressure drop (ΔP) were considered as optimization objects. The investigated geometrical parameters of the wavy channels are amplitude ratio (b/H), phase shift (φ), and number of waves (Nw). The obtained optimum values provide a trade-off between heat transfer coefficient and pressure drop in the channels. The designer can select optimum values according to the required design factors.