Burden prediction is a vital task in the production blasting. Both the excessive and insufficient burden can significantly affect the result of blasting operation. The burden which is determined by empirical models is often inaccurate and needs to be adjusted experimentally. In this paper, an attempt was made to develop an artificial neural network (ANN) in order to predict burden in the blasting operation of the Mouteh gold mine, using considering geomechanical properties of rocks as input parameters. As such here, network inputs consist of blastability index (BI), rock quality designation (RQD), unconfined compressive strength (UCS), density, and cohesive strength. To make a database (including 95 datasets), rock samples are used from Iran’s Mouteh goldmine. Trying various types of the networks, a neural network, with architecture 5-15-10-1, was found to be optimum. Superiority of ANN over regression model is proved by calculating. To compare the performance of the ANN modeling with that of multivariable regression analysis (MVRA), mean absolute error (Ea), mean relative error (Er), and determination coefficient (R2) between predicted and real values were calculated for both the models. It was observed that the ANN prediction capability is better than that of MVRA. The absolute and relative errors for the ANN model were calculated 0.05 m and 3.85%, respectively, whereas for the regression analysis, these errors were computed 0.11 m and 5.63%, respectively. Moreover, determination coefficient of the ANN model and MVRA were determined 0.987 and 0.924, respectively. Further, a sensitivity analysis shows that while BI and RQD were recognized as the most sensitive and effective parameters, cohesive strength is considered as the least sensitive input parameters on the ANN model output effective on the proposed (burden).