In the present work, we report synthesis of anchored palladium complex on functionalized Fe3O4 nanoparticles via simple and inexpensive procedure. The prepared nanohybrid compound was characterized by FT-IR, SEM and TGA measurements. The catalytic activity of Fe3O4-Serine-Pd as an efficient and reusable catalyst was investigated for synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives. Keywords (11 Bold): Pd(0)-complex, Magnetic nanoparticle, 2,3-dihydroquinazolin-4(1H)-one