Two proton-transfer metal–organic compounds that formulated as, [Cu(pydc)2].3H2o (1), [Ni(pydc)2].3H2o (2) synthesized and characterized by elemental analysis single-crystal diffraction,, infrared spectroscopy, TGA/DTA and antimicrobi al studies where pydc is pridine- 2,6-dicarboxylic. Microbiological activity of complexes were studied against some bacteria and fungus.