محمد قادرمزی

Multidentate heterocyclic ligands of pyridylcarboxamides have an important position in biochemistry and coordination chemistry. [1]. Metal ions with capability of substituting for amidic hydrogen can coordinate strongly to the amide group [2]. A large number of high-valence copper complexes with amide-based ligands were investigated as biomimetic models and catalytic oxidants [4]. These results, along with our interest to design new compounds with catalytic and cytotoxic activity, led us to synthesize and study of new amidic ligands from the reaction of pyridine-2,6-dicarboxylic acid and 2-aminobenzoic acid and also, a Cu(II) complex from (L1) (Scheme 1) [5]. It is noteworthy that despite high stability of amide groups [6], X-ray studies exhibited that one of the amidic bonds was hydrolyzed during the complexation of ligand (L1) [7] and an unsymmetrically polymeric Cu(II) complex was synthesized. In this paper, possible mechanisms and some effective factors on the hydrolysis of amides are discussed.