Internal control system is implemented by the management or those charged with governance to assure that entity’s objectives regarding reporting, compliance with applicable laws and effectiveness and efficiency of operations is achieved. In the financial sector, the success of internal control depends on the reliability of financial information. The purpose of this study is to investigate the impact of internal control components on the reliability of financial information. The population of this paper is Retailers, Food, Pharmaceutical and Healthcare Industries and the period of this study is the summer 2014. The needed data was gathered through questionnaire. In order to test the hypotheses, Chi-square test was used. According to the research results, there is a meaningful relationship between the components of internal control (including the control environment, risk assessment, control activities, information & communication, and monitoring) and the reliability of financial information. Among the components of internal control issues such as: leadership style, law & regulation, audit committee, adequate internal control structure, protection of assets and documentation, using external & internal auditors, accounting information systems have more impact on increasing the reliability of financial information. Besides, the issues such as: organizational chart, industrial design, industry rules, responsibility system and position of organization have least impact on the reliability of financial information.