The aim of the study is Strategic Information Systems Arrangement using information systems requires an understanding of the organization, management and the technology forming the systems. As the technology is developing extremely so are the opportunities to prepare the organization in the competitive advantage environment. In order to manage the IS/IT based systems; it is important to have a suitable strategy that defines the systems and provide to manage them. Strategic Information Systems Arrangement (SISA) is an effective method of developing and protection the IS/IT systems that support the business functioning. Arrangement of the IS/IT plans and the business plans is essential for improved business discharges, this research looks at the essential element of SISA in the changing business circumstances in Iran.