A new molecular imprinted polymer was synthesized by sol–gel procedure based on magnetic graphene oxide nanoparticles (MGMIP) toward creatinine. Accordingly, creatinine is a crop of metabolism in the muscles excreted from the kidneys, its measurement is a good approach to evaluate the function of the kidneys. The sol–gel process was used to prepare MGMIP with Tetraethoxysilane as a cross-linker, 3-aminopropyltriethoxysilane as a functional monomer, and creatinine as a template molecule at room temperature. The preparation of the polymer at room temperature as well as the non-use of initiator is known as the distinguishing features of this study. In the present study, MGMIP was characterized by Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), and field emission scanning electron microscopy (FESEM). In order to achieve maximum adsorption capacity (Qm) optimal values for pH, time, creatinine concentration, and amount of adsorbent were evaluated, while the other parameters were kept constant. According to the adsorption experiments conducted, the maximum adsorption occurred when the initial concentration of creatinine was 100 mg/l at pH 7 after 20 min adsorption by 30 mg of MGMIP (Qm = 75 mg/g). Thereafter, the selectivity of MGMIP was investigated in the presence of Creatine, L-tyrosine, and N-Hydroxysuccinimide. The adsorption isotherm and kinetic studies showed that the adsorption experimental data were more consistent with the Langmuir and pseudo-second-order models, respectively
