We study the holographic dark energy (HDE) model in generalized Brans-Dicke scenario with a non-minimal coupling between the scalar field and matter lagrangian namely Chameleon Brans Dicke (CBD) mechanism. In this study we consider the interacting and non-interacting cases for two different cutoffs. The physical quantities of the model such as, equation of state (EoS) parameter, deceleration parameter and the evolution equation of dimensionless parameter of dark energy are obtained. We shall show that this model can describe the dynamical evolution of fraction parameter of dark energy in all epochs. Also we find the EoS parameter can cross the phantom divide line by suitable choices of parameters without any mines kinetic energy term.
