Motivated by the recent works of one of us (Karami and Fehri, Int. J. Theor. Phys. 49:1118, 2010; Phys. Lett. B 684:61, 2010), we study the holographic dark energy in BransDicke gravity with the Granda-Oliveros cut-off proposed recently in literature. We find out that when the present model is combined with Brans-Dicke field the transition from normal state where w D > −1 to the phantom regime where w < −1 for the equation of state of dark energy can be more easily achieved for than when resort to the Einstein field equations is made. Furthermore, the phantom crossing is more easily achieved when the matter and the holographic dark energy undergo an exotic interaction. We also calculate some relevant cosmological parameters and their evolution. D
