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Jalal Rostamzadeh

Jalal Rostamzadeh

Academic rank: Assistant Professor
ORCID:
Education: PhD.
ScopusId: 15838043500
Faculty: Faculty of Agriculture
Address:
Phone: 3366

Research

Title
Association Of CTLA4 Gene 49A/G Polymorphism With The Incidence of Type 1 Diabetes Mellitus In the Iranian Kurdish Population
Type
JournalPaper
Keywords
type 1 diabetes, CTLA4, polymorphism, susceptibility, loci
Year
2013
Journal PAKISTAN JOURNAL OF BIOLOGICAL SCIENCES
DOI
Researchers Salahadin Ahmadi ، Jalal Rostamzadeh ، Darya Khosravi ، parvin Shariati Gazgazare ، adia shakiba

Abstract

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) has an inhibitory function on T cells and is critical for the induction of peripheral tolerance. CTLA-4 +49 G allele affects the CTLA-4 function and has been reported to be correlated with a higher risk of various autoimmune diseases including type 1 diabetes (TIDM). The present study was conducted to investigate the association between the polymorphism of the CTLA-4 exon 1 +49 A/G and susceptibility to TIDM in Kurds living in Iranian kurdistan. The +49 A/G polymorphism was analyzed in 64 patients with TIDM, 60 patients with type 2 diabetes (T2DM ) and 107 control subjects with no history of autoimmune disease using PCR-SSCP and PCR-RFLP methods..