The Urumieh-Dokhtar Magmatic Arc (UDMA) is part of the Alpine–Himalayan orogenic belt and interpreted to be a subduction-related Andean-type magmatic arc. Along this belt, Eocene volcanics and some gabbroic to granitic bodies crop out. The main rock types of the studied intrusion are granite, granodiorite, and diorite. They have geochemical features typical of magnesian, calc-alkaline, metaluminous to slightly peraluminous granites and I-type intrusive rock that have a strong enrichment in Large-Ion Lithophile (LIL) elements (e.g. Rb, Ba, Sr), and a depletion in High Field Strength (HFS) elements (e.g. Nb, Ti, P), typical of subduction-related magmas. Zircon U-Pb dating was applied to determine the emplacement ages of the different intrusions in the Ardestan area. Among them the Kuh-e Dom diorite is 53.9±0.4Ma old; the Kuh-e Dom granodiorite is 51.10±0.4Ma old; the Mehrabad granodiorite is 36.8±0.5Ma old, the Nasrand granodiorite is 36.5±0.5Ma old, the Zafarghand granodiorite is 24.6±1.0Ma old, and the Feshark granodiorite is 20.5±0.8Ma old. These results delineate more accurately the magmatic evolution related to the Neotethyan subduction from the Lower Eocene to Lower Miocene, and the subsequent Zagros orogeny that resulted from the Arabia-Eurasia collision. The emplacement of these intrusive rocks inside the UDMA, which has a close relationship with the collisional orogeny, is transitional from a subduction-related setting to post-collisional setting in the Ardestan area.