The aim of the current study was to compare women with premenstrual syndrome (PMS) and with women in a non-PMS group with regard to emotion regulation strategies and trait meta-mood dimensions. Based on the results of an interview and screening tool, a total of 252 female college students were assigned to two groups including 126 women with PMS and 126 non-PMS women. Participants completed the Emotion Regulation Questionnaire (ERQ) and Trait Meta-Mood Scale (TMMS). The results showed that the women with PMS scored signifcantly higher on suppression (d =2.35) and lower on reappraisal (d=0.50), emotional clarity (d=0.64) and emotional repair (d =0.81) compared to non-PMS women. Women with PMS had trouble regulating their emotions and didn’t use trait meta-mood strategies adaptively. The fndings of our study could help both researchers and clinicians better understand some of the psychological difculties experienced by women with PMS, and therefore explore and deliver efective interventions.