This paper deals with a reliability optimization problem for a series system with multiple-choice and budget constraints. The objective is to choose one technology for each subsystem in order to maximize the reliability of the whole system subject to the available budget. This problem is NP-hard and could be formulated as a binary integer programming with a nonlinear objective function. In this paper an efficient ant colony optimization (ACO) approach is developed for the problem. In the approach, a solution is generated by an ant based on both pheromone trails modified by previous ants and heuristic information considered as a fuzzy set. Constructed solutions are not guaranteed to be feasible; consequently, applying an appropriate procedure, an infeasible solution is replaced by a feasible one. Then, feasible solutions are improved by a local search. The proposed approach is compared with the existing metaheuristic available in the literature. Computational results demonstrate that the approach serves to be a better performance for large problems.