ISLAMIC AZAD UNIVERSITY MAHABAD BRANCH Introduction Obesity is a chronic pathology with high morbidity mortality rates witch, frequently associated with various metabolic disorders (such as dyslipidemia, high fasting glucose, etc). Hence, interventions for obesity should target multiple cardiovascular and metabolic risk factors. Exercise is a low-cost therapeutic lifestyle change that has been recommended for improving lipid and lipoprotein levels in obese, more- over, recently the use of herbal medicine as a pharmacologic modality in preventing alteration in lipid metabolism has received a wide attention. Therefore, this study was conducted to determine the effect of PRT and ginger supplementation on lipid profiles and body composition in obese men. Methodsdant supplement may improve plasma TAC and levels of oxidative stress. Hence this study was conducted to assess the effects of resis- Methods tance training and ginger supplementation on TAC and oxidative stress in obese men in a randomized double-blind design, Thirty-two obese male (BMI≥ 30, aged 18-30 years) were randomized to one of four groups: a placebo group (PL; n=8); resistance training plus placebo group (RTPL; n=8); supplement group (S; n=8) that subjects consumed 1 gr ginger/d for 10 wk; and a resistance training plus ginger group (RTS; C=8). Progressive resistance training was held three times a week for 10 weeks and included 7 exercises. At baseline and after 10 weeks Blood samples were collected from the antecubital vein and Plasma antioxidant capacity (TAC) by the FRAP method and malondialdehyde (MDA) as an indicator of oxidative stress, were measured The one-way ANOVA were used in the statistical analysis. Results After 10 weeks of intervention, we observed a significant decrease for MDA concentration and significant increase for plasma TAC in the RTPL, RTS and S groups (p<0.05).While it remained unchanged in PL group (p>0.05). Discussion Oxidative stress may play a critical role in the pathogenesis and development of obesity-associated co-morbidities (Melissas et al. 2006). In accordance with previous studies (Tinahones et al., 2008), our study revealed decreased plasma antioxidant and increased oxidative stress levels in obese subjects. However, as shown by other researches (Vincent et al., 2006), our results confirm that progres- sive resistance training for 10 week increases plasma antioxidant capacity and decreases oxidative stress. Moreover, in consistent to Afshari et al study (2007) our results indicated that plasma TAC augmented and thus decreases plasma MDA when consuming herbal extracts (such as ginger) containing antioxidants. Therefore, according to the results of this and previous studies it can be said, that, resistance training and ginger supplementation have been effective therapeutic devises to favourable changes in plasma total antioxi- dant and oxidative stress in obese individual. References Afshari AT, Shirpoor A, Farshid A, Saadatian R, Rasmi Y, Saboory E, Allameh A. (2007). J Food Chemistry 101 148-153. Melissas J, Malliaraki N, Papadakis J, Taflampas P, Kampa M, Castanas E. (2006). J Obesity Surgery, 314-320(7). Tinahones FJ, Pierri M, Sánchez L, Almeida J, Serrano S, Arnés J, Fuentes E. (2008). Obesity, 17(2), 240-246. Vincent HK, Bourguignon C, Vincent KR. (2006). J Obesity, 14, 1921-1930.
