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Asaad Vaziry

Asaad Vaziry

Academic rank: Associate Professor
ORCID:
Education: PhD.
ScopusId: 23096216500
HIndex:
Faculty: Faculty of Agriculture
Address: Faculty of Agriculture, University of Kurdistan, kuedistan, Iran Telephon : 6664600-8 Postal code : 66177-15177
Phone: +98 87 33620552

Research

Title
Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies
Type
JournalPaper
Keywords
Mouse Cytomegalovirus, Breast Cancer, Human cytomegalovirus, MCK-2 Gene
Year
2014
Journal Archives of Razi Institute
DOI
Researchers Fatemeh Abedini ، Mojtaba Moharrami ، Pegah Shams ، Mohamad Eslampanah ، Hamide Adeldust ، Mohamad Ebrahimi ، Asaad Vaziry ، Fatemeh Talebloo

Abstract

Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on breast cancer.