Silver-nanoparticles (AgNPs) are emerging as one of the fastest growing product categories in the nanotechnology industry with focus on antimicrobial activity. This nanoparticle was being used as a disinfectant in the poultry industry. More studies are needed to do for finding the adverse effects of AgNPs. The aim of this study was to investigate the effects of AgNPs in drinking water on performance, carcass characteristics and Hematological parameters. This research was carried out on 72 one-day-old quails (Coturnix japonica) in a completely randomized design (CRD) in four treatments at 0 (control), 4, 8 and 12-ppm of silver nanoparticles that was added daily to drinking water with six repetitions. The effect of the different AgNPs levels was determined using the General Linear Model of SAS procedure, whilst differences between the groups were determined using Duncan test. The results showed that there were no significant differences in mean body weight gain, feed intake and feed conversion ratio of quail between treatments. Results showed that body weight, feed intake, weight gain and feed conversion ratio were not significantly (P>0.05) affected. Relative liver and kidney weights (ratios to body weights) were significantly (P<0.05) increased in treatments compared to control. While there weren`t any differences in carcass characteristics include relative weight of heart, spleen, bursa of fabricius, jejunum, ileum, duodenum, proventriculus , gizzard, hematological parameters such as hemoglobin, red blood cell, packed cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular and the percentage of lymphocyte, monocyte, basophil, eosinophil and heterophil to lymphocyte ratio. Whilst The results revealed that White Blood Cell count and percentage of heterophil in quails that received 12 ppm AgNPs were significantly higher than others (P<0.05). The results of the present study suggest that silver nanoparticles may have an eff
