The compassion focused therapy is a form of treatment that is developer combination of cognitive therapy that based skill with training. According to this issue that borderline personality disorder is one of the most famous psychological disorder, this study examined the effectiveness of compassion focused therapy on improvement depression have a history of self-mutilation borderline patient syndrome.The population status in this study is among patients in a psychiatrist's office (1girl, 2boy). By means of cognizing borderline personality and according to their willingness and comparing with the research criterions, they are selected with the available sampling. Research instrument include: million clinical multiaxial inventory, the beck depression inventory, self-compassion scale. Collected Data from all sessions were depicted as graphs and tables, including percent changes. The results revealed the effectiveness of compassion focused therapy for improving depression borderline personality disorder . The conclusion of this study, impacting therapy based on compassion in improvement depression of border patients has background of self-mutilation.