Background. According to World Health Organization, the global population of diabetes is approximately 463 million people and is projected to exceed half a billion by 2030. There is currently no specific cure for diabetes, but the methods of control and management are advancing. The effect of exercise and physical activity on one of the latest involved factors, WISP-1 and WISP-2, is one of the therapeutic strategies. Objectives. This study aims to answer the question of what effect circular resistance training has on WISP-1 and WISP-2 in individuals with type 2 diabetes (T2DM). Methods. Among men with T2DM referred to the Diabetes Clinic of Towhid Hospital and the Diabetes Association of Sanandaj, a total of 20 eligible volunteers were randomly assigned to two groups of 10, control and experimental. Circuit resistance training was used in this study for eight weeks, with three non-consecutive sessions per week. The number of sets, intensity, and volume of exercise started with 2 sets at 40% of 1RM (one-repetition maximum) and 15 repetitions in the initial sessions and progressed to 4 sets at 80% of 1RM and 6 repetitions in the final sessions. Rest periods of 20 to 30 seconds between sets and 3 minutes between rounds were considered. WISP-1 and WISP-2 levels were measured via ELISA method. Results. WISP-1 and -2 levels in the control group lake a significant change over time, its levels in the experimental group significantly decreased (p=0.029 and p=0.039, respectively). Conclusion. Both WISP-1 and WISP-2 likely have an impact on the mechanisms of glucose homeostasis, insulin, insulin resistance, and body weight in individuals with T2DM.
