Abstract- Obesity and associated chronic inflammation lead to insulin resistance. The aim of this study was to evaluate the effect of varying intensity circuit resistance training on metabolic and inflammatory markers in obese men. In a semi-experimental trial, 44 obese men were selected and randomly divided into four groups, including 1) Control (n=11), 2) Low-intensity circuit resistance training (n=11), 3) Moderate-intensity circuit resistance training (n=11), and 4) High-intensity circuit resistance training (n=11). Resistance training was performed at different intensities, including 1) High-intensity circuit resistance training (80% 1RM), 2) Moderate-intensity circuit resistance (60% 1RM), and 3) Low-intensity circuit resistance training (40% 1RM), three sessions per week for 12 weeks. Serum levels of Dectin-1, TLR2, TLR4, MyD88 were measured using an ELISA kit. Data were analyzed with covariance analysis at P<0.05. Twelve weeks of moderate and highintensity circuit resistance training significantly reduced weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR (P=0.001). The reduction of weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR were significant in obese men in the high-intensity training group compared to low-intensity training (P=0.001). It seems that circuit resistance training, especially highintensity circuit resistance training, can be used as an option to reduce the inflammatory and metabolic complications associated with obesity. © 2021 Tehran University of Medical Sciences. All rights reserved.
