Objective: Erectile dysfunction (ED) is a sexual disorder where sexual arousal/action fails to cause or maintain an erect penis. Based on ED statistics 2022-23, the ED worldwide incidence will increase from 152 million men in 1995 to 322 million men by the year 2025. ED can be treated with a variety of drugs and supplements available from medication outlets. However, not all are beneficial or available to global populations, and some have negative effects. The fact that vascular, neurological, and hormonal dysfunction are the three main physiological and biochemical factors that contribute to ED may be the cause of its ineffectiveness. It is suggested that the three combinations listed above are all caused by inflammation. Thus, research is needed to address ED in non-pharmacological way that targets inflammation. This review aims to highlight the importance of “Intermittent hypoxia training (IHT)” in targeting inflammation for treating ED. Methods: A structured search strategy was conducted in PubMed and Google Scholar to search for publications in English using the search term “Erectile Dysfunction”
