The biofluids being manipulated in lab-on-a-chip devices usually contain elastic macromolecules. Accordingly, for an accurate modeling of the relevant flow physics one should invoke viscoelastic constitutive equations. In this paper, attention is paid toward the hydrodynamic dispersion by the fully developed electroosmotic flow of PTT viscoelastic fluids in slit microchannels of low zeta potential. Adopting the Taylor–Aris approach, analytical solutions are derived for late-time solute concentration and effective dispersion coefficient. Finite element-based numerical simulations are also conducted to monitor the broadening of an analyte band from the moment of injection. Both approaches are found to be in a good agreement with an average error of below 8% in the calculated dispersion coefficients. It is observed that, for given zeta potential and electrolyte type, the hydrodynamic dispersion is severely pronounced by increasing the level of elasticity in the fluid. The variations are reversed and less pronounced when the analysis is made for a fixed mean flow rate. Moreover, the effective dispersivity grows by thickening the EDL when it is sufficiently thin, whereas the opposite is true for thick EDLs. Finally, an inspection of the average concentration reveals the formation of tails for thick EDLs that may reduce the resolution in sensing applications.
