Amines are found in the structure of important pharmacologically active compounds, as well as biologically active for example neurotransmitters. Due to the high importance of amines, several methods have been developed for their synthesis such as the addition reaction of solfunamide compounds [1]. Nowadays, numerous organic compounds such as amines were synthesized through the reaction between amide derivatives and boron reagents. The use of immobilized catalysts on the magnetic supports with the advantage of catalyst separability and recyclability, is one of the suitable developed strategies in recent years. Among the different types of used supports in heterogeneous catalysis, Pd on Fe3O4 has been employed as useful and versatile nanomagnetic catalyst [2]. The use of boron reagents 1 as a source of aryl through the exchange of aryl groups between boron and metal is one of the most commonly used methods for the arylation of solfunamide [3]. In this work, amine derivatives were synthesized by N-arylation of p-toluene sulfonamide 2 in the presence of a hetrogenouse catalyst Pd/Fe3O4 and phosphine ligand on the optimum condition in excellent yields and short reaction time (Scheme 1). The structure of the catalyst was characterized via SEM, EDAX, TGA and FT-IR techniques, and the prepared products were identified by melting point and IR, 1HNMR, and 13C NMR spectral analysis.
