اکرم آشوری

Enantioselective allylic oxidation of alkenes using organic peresters and copper chiral complexes has been a subject of great interest during the last decade. This reaction provides an access to chiral allylic alcohols which are key intermediates in synthesis of natural products. Several organometallic catalysts were developed using a great variety of ligands that were used as asymmetry inductors. Among them, chiral C2-symmetric bis(oxazolines) (box’s) are one of the most effective and popular classes of chiral ligands for various metal-catalyzed asymmetric processes. Here in, chiral biphenyl bisoxazoline ligands were synthesized from 2-amino benzoic acid and potential of these ligands for copper-catalyzed allylic oxidations of olefins was investigated in the Presence of several additives. In summary, The synergic effect of water and the molecular sieves was examined for oxidation of various cycloolefins, high catalytic activities, enantioselectivities up to 92% and 99% yield were obtained by using this combination of additives.