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Abstract
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Benzofurans possess a broad range of biological activities, and have been subject of extensive studies. Cyclization reaction of various types have been used to produce substituted benzofurans. The reaction between hvdroxybenzaldehyde, isocyanides, and arnmonium formate, in the conditition of Ugi four componcnt condensation, is reported to afford 2alkylamino3- hydroxyhenzyllidene)amino]benzofurans. As part of our current studies on development of new routes to heterocyclic systems, we now report the reaction between alkyl isocyanides 2 and 2hydroxybenzaldehyde or hydroxy-5-nitrobenzaldehyde in CH2CI2, which leads to 2-alkylamino hydroxybenzofuran derivatives 3 in moderate yield.
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