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Title
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Synthesis of pyrrolo[2,1-a]isoquinolines from activated acetylenes, benzoylnitromethanes, and isoquinoline
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Type
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JournalPaper
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Keywords
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Pyrroloisoquinoline Benzoylnitromethane Activated acetylenes N-Heterocycles Isoxazoles
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Abstract
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Isoquinoline reacts smoothly with aroylnitromethanes in the presence of dialkyl acetylenedicarboxylates and dibenzoylacetylene to produce pyrrolo[2,1-a]isoquinolines in good yields. Quinoline and benzothiazole also react in a similar way. Pyridine and N-methylimidazole catalyze the reaction between nitromethane derivatives with electron-deficient acetylenes to produce highly functionalized isoxazoles.
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Researchers
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Loghman Moradi (Third Researcher), Mohammad piltan (Second Researcher), yavari Issa (First Researcher)
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