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Title
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Stereoselective reaction between N1-benzyl-4-methyl-1-benzenesulfonamide derivatives with dimethyl acetylenedicarboxylate and antimicrobial activities of related N-vinylated products
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Type
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Presentation
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Keywords
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Solfonamides, Vynilation, Sodium azid, Acetylenic esters
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Abstract
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Sulfonamides receive considerable attention in the literature, as a consequence of their exciting biological properties [1]. We have perversely reported the stereoselective reaction between phenols and dimethyl acetylenedicarboxylate (DMAD) [2]. In this work we wish to report the stereoselective syn addition of sulfonamides 1 to dimethyl acetylenedicarboxylate in the presence of tetrabutylammonium bromide (TBAB) and sodium azid at room temperature to produce N-vinylated products 2. Gram-positive and Gram-negative bacteria are a significant cause of hospital acquired and community infections and may induce diseases associated with serious levels of morbidity and mortality. Moreover, antibiotic resistance of Grampositive pathogens, such as Staphylococcus aureus, Escherichia coli, Enterobacter earogenes, and Pseudomonas aeruginosa has become one of the major worldwide health problems [3]. The activity against Gram-positive and Gram-negative bacteria of vinylated products 2 were tested in vitro using two reference bacterial strains. e.g. Staphylococcus aureus and Escherichia coli. These compounds were active against both strains tested by disk diffusion method in ranging from 10 to 15 mm per 2 μg disk.
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Researchers
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Zeynab Azimian (Third Researcher), Rashid RamazanZadeh (Second Researcher), Farough Nasiri (First Researcher)
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